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FLASH GENE
Symbol CYP2U1 contributors: mct/shn - updated : 12-03-2013
HGNC name cytochrome P450, family 2, subfamily U, polypeptide 1
HGNC id 20582
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly Homo sapiensNM_183075
 heart   moderately Homo sapiensNM_183075
 heart   lowly Homo sapiensNM_183075
Lymphoid/Immunethymus   highly Homo sapiensNM_183075
 thymus   predominantly Homo sapiensNM_183075
Nervousbrain   moderately Homo sapiensmRNA
 brainhindbraincerebellum predominantly Homo sapiensNM_183075
Respiratorylung   lowly Homo sapiensNM_183075
Urinarykidney   lowly Homo sapiensNM_183075
cell lineage
cell lines
fluid/secretion
at STAGE
Text thymus
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cytochrome P450 functional domain
    • HOMOLOGY
    interspecies ortholog to Cyp2u1, Mus musculus
    ortholog to Cyp2u1, Rattus norvegicus
    ortholog to cyp2u1, Danio rerio
    intraspecies homolog to CYP2R1
    Homologene
    FAMILY P450 family 2
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text partially colocalized with endoplasmic reticulum and mitochondria
    basic FUNCTION
  • involved in an NADPH-dependent electron transport pathway
  • metabolizing long chain fatty and playing an important physiological role in fatty acid signaling processes in both cerebellum and thymus
  • may play an important role in modulating the arachidonic acid signaling pathway
  • plays an important physiological role in fatty acid signaling processes in both cerebellum and thymus
  • exhibits few genetic variations, supporting a probable role in endogenous processes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    text catalyzed the hydroxylation of structurally related long chain fatty acid (docosahexaenoic acid)
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG56
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS