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FLASH GENE

Symbol

CYP2U1

contributors: mct/shn - updated : 12-03-2013

HGNC name	cytochrome P450, family 2, subfamily U, polypeptide 1
HGNC id	20582

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_183075 5 - 4760 NP_898898 - 544 - 2004 14975754

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Homo sapiens NM_183075   heart       moderately Homo sapiens NM_183075   heart       lowly Homo sapiens NM_183075 Lymphoid/Immune thymus       highly Homo sapiens NM_183075   thymus       predominantly Homo sapiens NM_183075 Nervous brain       moderately Homo sapiens mRNA   brain hindbrain cerebellum   predominantly Homo sapiens NM_183075 Respiratory lung       lowly Homo sapiens NM_183075 Urinary kidney       lowly Homo sapiens NM_183075

cell lineage

cell lines

fluid/secretion

at STAGE

Text

thymus

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a cytochrome P450 functional domain

HOMOLOGY

interspecies	ortholog to Cyp2u1, Mus musculus
	ortholog to Cyp2u1, Rattus norvegicus
	ortholog to cyp2u1, Danio rerio

intraspecies

homolog to CYP2R1

Homologene

FAMILY

P450 family 2

CATEGORY

enzyme , transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	partially colocalized with endoplasmic reticulum and mitochondria

basic FUNCTION	involved in an NADPH-dependent electron transport pathway
	metabolizing long chain fatty and playing an important physiological role in fatty acid signaling processes in both cerebellum and thymus
	may play an important role in modulating the arachidonic acid signaling pathway
	plays an important physiological role in fatty acid signaling processes in both cerebellum and thymus
	exhibits few genetic variations, supporting a probable role in endogenous processes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

text	catalyzed the hydroxylation of structurally related long chain fatty acid (docosahexaenoic acid)

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPG56

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS