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FLASH GENE

Symbol

TET1

contributors: mct/ - updated : 09-03-2021

HGNC name	tet oncogene 1
HGNC id	29484

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       to MLL in acute myeloid leukemia with trilineage dysplasia in t(10;11)(q22;q23) constitutional       loss of function would promote the stochastic hypermethylation of promoters leading to deregulation of transcription and differentiation constitutional     --low   depletion of TET1 leads to down-regulation of meiotic genes, which causes defective meiotic prophase including accumulation of non-repaired DSBs, and formation of univalent chromosomes

Susceptibility

to late-onset Alzheimer's disease

Variant & Polymorphism SNP	increasing the risk of late-onset Alzheimer's disease

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology inflammatory   TET1 enzyme could be a promising therapeutic target to inhibit the persistent inflammation caused by macrophages in chronic inflammatory diseases

ANIMAL & CELL MODELS