is essential for the cotranslational insertion of sec into selenoproteins
may be involved in preventing termination at the UGA/sec codon
remains ribosome bound except during selenocysteine delivery to the ribosomal A-site
protein of the Sec incorporation machinery, having transcription and translation regulated in a coordinated manner in response to stress (Papp 2008)
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
binding
small molecule
protein
EIF4A3 interaction with the selenoprotein mRNA prevents the binding of SECISBP2, which is required for selenocysteine insertion, thereby inhibiting the synthesis of the selenoprotein