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FLASH GENE
Symbol OSR2 contributors: mct/pgu - updated : 28-02-2024
HGNC name odd-skipped related 2 (Drosophila)
HGNC id 15830
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Osr2 (98.9 pc)
homolog to murine Osr2 (97.5 pc)
intraspecies homolog to ODD
Homologene
FAMILY
  • Odd C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in embryonic skeletal system morphogenesis
  • playing a role in positive regulation of cell proliferation
  • acting as a key intrinsic regulator of palatal growth and patterning
  • functions in regulation of osteoblast proliferation
  • plays an important role in cellular quiescence and proliferation under epigenetic regulation
  • plays important roles in proliferation and development
  • OSR1 and OSR2 function is required for maintenance of expression of signaling molecules critical for joint formation, including GDF5, WNT4 and WNT9B
  • OSR1 and OSR2 function redundantly to control synovial joint formation
  • acts downstream of PAX9 and patterns the mesenchymal odontogenic field through protein-protein interactions with MSX1 and PAX9 during early tooth development
  • BMP4-MSX1 pathway and OSR2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt antagonists
  • is a key intrinsic regulator of palatal shelf growth and morphogenesis
  • OSR2 controls multiple molecular pathways, including BMP and SEMA3 signaling, in palate development
  • role of OSR2 downregulation in erasing the mesenchymal phenotype at an early stage of somatic cell reprogramming
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
  • BMP4-MSX1 pathway propagates mesenchymal activation for sequential tooth induction and spatial modulation of this pathway provides a mechanism for patterning vertebrate dentition
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • BMP4 signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including DKK2 and OSR2, and synergizes with MSX1 to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation
  • MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion
    • cell & other
    REGULATION
    Other regulated by CEBPA regulatory elements
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    highly methylated (85 p100 or more) in cancer cells (Gastric cancer)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking the transcription factor odd-skipped related-2 (Osr2) develop supernumerary teeth lingual to their molars because of expansion of the odontogenic field
  • Osr2(-/-) mutant mice had only subtle defects in synovial joint development