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FLASH GENE
Symbol OSR2 contributors: mct/pgu - updated : 28-02-2024
HGNC name odd-skipped related 2 (Drosophila)
HGNC id 15830
DNA
TYPE functioning gene
STRUCTURE 7.66 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D8S257 - D8S1749 - OSR2 - D8S1789 - D8S559 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1825 30.4 276 - 2005 15670784
  • three zinc-finger motives
  • activated transcription
    • 4 splicing 1907 35.4 312 - 2005 15670784
  • repressed transcriptional activity
  • five zinc-finger domains
    • 5 - 2083 - 433 - 2005 15670784
    4 - 1563 - 228 - 2005 15670784
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Endocrineplacenta    
    Reproductivefemale systemovary   
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Osr2 (98.9 pc)
    homolog to murine Osr2 (97.5 pc)
    intraspecies homolog to ODD
    Homologene
    FAMILY
  • Odd C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in embryonic skeletal system morphogenesis
  • playing a role in positive regulation of cell proliferation
  • acting as a key intrinsic regulator of palatal growth and patterning
  • functions in regulation of osteoblast proliferation
  • plays an important role in cellular quiescence and proliferation under epigenetic regulation
  • plays important roles in proliferation and development
  • OSR1 and OSR2 function is required for maintenance of expression of signaling molecules critical for joint formation, including GDF5, WNT4 and WNT9B
  • OSR1 and OSR2 function redundantly to control synovial joint formation
  • acts downstream of PAX9 and patterns the mesenchymal odontogenic field through protein-protein interactions with MSX1 and PAX9 during early tooth development
  • BMP4-MSX1 pathway and OSR2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt antagonists
  • is a key intrinsic regulator of palatal shelf growth and morphogenesis
  • OSR2 controls multiple molecular pathways, including BMP and SEMA3 signaling, in palate development
  • role of OSR2 downregulation in erasing the mesenchymal phenotype at an early stage of somatic cell reprogramming
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
  • BMP4-MSX1 pathway propagates mesenchymal activation for sequential tooth induction and spatial modulation of this pathway provides a mechanism for patterning vertebrate dentition
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • BMP4 signaling suppresses tooth developmental inhibitors in the tooth mesenchyme, including DKK2 and OSR2, and synergizes with MSX1 to activate mesenchymal odontogenic potential for tooth morphogenesis and sequential tooth formation
  • MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion
    • cell & other
    REGULATION
    Other regulated by CEBPA regulatory elements
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    highly methylated (85 p100 or more) in cancer cells (Gastric cancer)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking the transcription factor odd-skipped related-2 (Osr2) develop supernumerary teeth lingual to their molars because of expansion of the odontogenic field
  • Osr2(-/-) mutant mice had only subtle defects in synovial joint development