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FLASH GENE
Symbol PRUNE2 contributors: mct/npt - updated : 09-07-2015
HGNC name prune homolog 2 (Drosophila)
HGNC id 25209
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • P-loop and a coiled-coil region near the N-terminus
  • a Bcl2-/adenovirus E1B interacting protein 2 (BNIP2)
  • Cdc42GAP homology domain in the C-terminus, with caspase cleavage sites upstream of the C-terminal BCH domain (Valencia 2007)
    • HOMOLOGY
    interspecies ortholog to PRUNE
    Homologene
    FAMILY BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells (neuroblastoma)
  • BCH domain-containing protein implicated in programmed cell death (cleaved by caspases during apoptosis)(Valencia 2007)
  • could suppress cellular transformation by preventing sustained Rho activation in concert with restricting RHOA and AKAP13 binding via its BCH domain
  • involved in the regulation of protein degradation, apoptosis, neuronal loss and neurodevelopment
  • may contribute to the maintenance of mature nervous systems
  • novel role for BMCC1 in post-endocytic trafficking
  • is an AP2 associated endosomal protein in prostate cancer cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • PRUNE2 binds to 8-oxo-GTP, an oxidized form of GTP
    • protein interacting with RHOA, RHOC, and BNIP2 (Soh 2008)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in neuroblastoma with favorable prognosis
    tumoral     --over  
    during NGF-depletion-induced apoptosis in neuroblastoma and was involved in the regulation of differentiation, survival, and aggressiveness of tumor cells (Valencia 2007)
    tumoral     --over  
    increased PRUNE2 protein expression may serve as a favorable prognostic marker in human leiomyosarcoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS