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FLASH GENE

Symbol

PRUNE2

contributors: mct/npt - updated : 09-07-2015

HGNC name	prune homolog 2 (Drosophila)
HGNC id	25209

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001308047 - - 12522 NP_001294976 336.91 3055 - 2012 23059019 BNIPXL-beta NM_015225 19 - 12602 NP_056040 340.63 3088 - 2012 23059019 BNIPXL-alpha PRUNE2 variant - - - - - expressed predominantly in the olfactory bulb and layer Ia of the piriform cortex 2012 23059019 Olfaxin contains a BCH motif and localizes predominantly to the synaptic cytosol, similar to ATCAY may develop new roles for Prune2 at the synapse in olfactory systems NM_001308048 - - 12525 NP_001294977 - 3063 - 2012 23059019 NM_001308049 - - 4587 NP_001294978 - 337 - 2012 23059019 NM_001308050 - - 4542 NP_001294979 40.09 352 - 2012 23059019 NM_001308051 - - 4458 NP_001294980 - 324 - 2012 23059019

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly Nervous brain       highly Homo sapiens   nerve cranial nerve trigeminal nerve   highly Homo sapiens   spinal cord sensory ganglia dorsal root     Homo sapiens   spinal cord anterior horn       Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	P-loop and a coiled-coil region near the N-terminus
	a Bcl2-/adenovirus E1B interacting protein 2 (BNIP2)
	Cdc42GAP homology domain in the C-terminus, with caspase cleavage sites upstream of the C-terminal BCH domain (Valencia 2007)

HOMOLOGY

interspecies

ortholog to PRUNE

Homologene

FAMILY

BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells (neuroblastoma)
	BCH domain-containing protein implicated in programmed cell death (cleaved by caspases during apoptosis)(Valencia 2007)
	could suppress cellular transformation by preventing sustained Rho activation in concert with restricting RHOA and AKAP13 binding via its BCH domain
	involved in the regulation of protein degradation, apoptosis, neuronal loss and neurodevelopment
	may contribute to the maintenance of mature nervous systems
	novel role for BMCC1 in post-endocytic trafficking
	is an AP2 associated endosomal protein in prostate cancer cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	PRUNE2 binds to 8-oxo-GTP, an oxidized form of GTP

protein

interacting with RHOA, RHOC, and BNIP2 (Soh 2008)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in neuroblastoma with favorable prognosis tumoral     --over   during NGF-depletion-induced apoptosis in neuroblastoma and was involved in the regulation of differentiation, survival, and aggressiveness of tumor cells (Valencia 2007) tumoral     --over   increased PRUNE2 protein expression may serve as a favorable prognostic marker in human leiomyosarcoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS