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FLASH GENE
Symbol RBP1 contributors: np/mct - updated : 28-10-2010
HGNC name retinol binding protein 1, cellular
HGNC id 9919
PROTEIN
PHYSICAL PROPERTIES other
STRUCTURE
motifs/domains
an internal ligand binding site
secondary structure a single eight-stranded continuously hydrogen-bonded antiparallel beta-barrel
mono polymer monomer
HOMOLOGY
interspecies ortholog to murine Rbp1
ortholog to rattus rbp1
Homologene
FAMILY
  • cellular, lipocalin family, Kernel group
    • CATEGORY chaperone/stress , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • essential for vitamin A homeostasis
  • involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue
  • reducing the oxidation of all-trans retinol by RDH12
  • small cytosolic binding protein for retinol and retinaldehyde, specifically expressed in preadipocytes that regulates adipocyte differentiation in part by affecting PPARG activity
  • influences photoreceptor outer segment assembly through a mechanism unrelated to rhodopsin regeneration, and have a role in modulating the proper folding of nascent outer segment membranes through retinoic acid
  • having an important role as a non-transcriptionally active preadipocyte factor that is involved in adipocyte differentiation
  • play different roles in the maintenance of vitamin A homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism vitamin
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds retinol and its immediate oxidation product retinaldehyde
  • binds to the pocket region of RB1 via an LXCXE motif and to the SAP30 subunit of the mSin3·HDAC complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    early in cervical carcinogenesis
    constitutional       loss of function
    leads to a proadipogenic phenotype with significantly enhanced adipocyte differentiation and increased intracellular TG accumulation due to augmented PPAR{gamma} activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS