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FLASH GENE
Symbol ATP2B4 contributors: mct - updated : 26-03-2011
HGNC name ATPase, Ca++ transporting, plasma membrane 4
HGNC id 817
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal domain referred to as a regulatory domain
  • 10 transmembrane domains
  • two large intracellular loops
  • and N- and C-terminal cytoplasmic tails
    • HOMOLOGY
    interspecies ortholog to murine Atp2b4
    ortholog to rattus atp2b4
    Homologene
    FAMILY P-type primary ion transport ATPases family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating the extrusion of CA2+ from the cell
  • magnesium-dependent enzyme catalyzing the hydrolysis of ATP coupled with the transport of calcium out of the cell
  • extrude Ca2+ from cells, maintaining the resting level of intracellular Ca2+ and controlling the Ca2+ transients induced by agonists
  • importance of oligomerization for the regulation of ATP2B4 activity and intracellular calcium concentration
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Ca(2+) homeostasis in sperm is maintained by the relative ratios of CASK-ATP2B4 and CASK-F11R interactions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS