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FLASH GENE

Symbol

RAX2

contributors: mct - updated : 21-01-2025

HGNC name	retina and anterior neural fold homeobox 2
HGNC id	18286

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	CORD11 retinal cone-rod dystrophy 11 RP95 retinitis pigmentosa 95
Location	19p13.3      Physical location : 3.769.095 - 3.772.219
Synonym name	retina and anterior neural fold homeobox like 1
	Q50-type retinal homeobox protein
Synonym symbol(s)	ARMD6, CORD11, MGC15631, QRX, RAXL1, RP95

DNA

TYPE	functioning gene
STRUCTURE	3.14 kb     3 Exon(s)

regulatory sequence	Binding site
text structure	a putative binding element for forkhead transcription factors is necessary for promoter activity and can cooperate with other cis-acting elements to drive RAX2A promoter activity

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001319074 3 - 2421 NP_001306003 - 184 - 2004 15028672 NM_032753 3 - 2190 20 184 - 2004 15028672

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous nerve cranial nerve       Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a homeobox DNA-binding domain
	an OAR domain

HOMOLOGY

interspecies

homolog to bovine Qrx

Homologene

FAMILY	RAX family
	bicoid subfamily

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	involved in the development and function of photoreceptors
	playing a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation
	is essential for eye development of several vertebrate species by modulating the proliferation and differentiation of retinal cells
	is an oncogenic factor in glioblastoma cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CRX
	BDNF-AS could elicit RAX2 mRNA decay through STAU1-mediated decay (SMD), and thereby regulated the malignant behaviors glioblastoma cells
	RAX2 increased the expression of DLG5 by binding to the promoter of DLG5

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CORD11 , RP95

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in glioma tumors

Susceptibility

to macular degeneration, age-related

Variant & Polymorphism other

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS