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FLASH GENE
Symbol MED13 contributors: mct - updated : 09-05-2019
HGNC name mediator complex subunit 13
HGNC id 22474
Corresponding disease
MRSSF mental retardation syndromic with speech delay and mild facial dysmorphisms
Location 17q23.2      Physical location : 60.019.966 - 60.142.643
Synonym name
  • thyroid hormone receptor-associated protein, 240 kDa subunit
  • vitamin D3 receptor-interacting protein complex component DRIP250
  • activator-recruited cofactor 250 kDa component
  • mediator of RNA polymerase II transcription, subunit 13 homolog
  • vitamin D3 receptor-interacting protein complex component
  • Synonym symbol(s) TRAP240, KIAA0593, THRAP1, DRIP250, HSPC221, ARC250
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 122.68 kb     30 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located in the 17q23 amplicon, in breast cancer
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 10474 239.2 2174 - Gu (1999)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivefemale systemplacenta  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal domain (aa 11–383)
  • two ligand-dependent nuclear hormone receptor signature recognition motifs (LXXLL sequences) at positions 1188-1192 and 1279-1283
  • a short leucine zipper at position 1331-1352
  • a C-terminal domain (aa 1640–2163)
  • HOMOLOGY
    intraspecies paralog to MED13L
    Homologene
    FAMILY
  • mediator complex subunit 13 family
  • CATEGORY receptor nuclear
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be involved in transcription initiation from Pol II promoter
  • regulation of transcription
  • DNA-dependent
  • androgen receptor signaling pathway
  • part of CDK8 subcomplex (containing CDK8, cyclin C, MED12, and MED13), functioning as a simple switch that controls the mediator–pol II interaction to help regulate transcription initiation and reinitiation events (Knuesel 2009)
  • exerts opposing metabolic actions in skeletal muscle and the heart, highlighting the customized, tissue-specific functions of the Mediator complex
  • MED13 acts within the heart to promote systemic energy expenditure in extra-cardiac energy depots
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • is a component of the CDK8-kinase module that can reversibly bind Mediator, a multi-protein complex that is required for Polymerase II transcription initiation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MED13/MED13L physically link the CDK8 module to Mediator, and FBXW7 loss increases CDK8 module-Mediator association
  • CDK8 and its paralog CDK19, in complex with CCNC, MED12 and MED13, are transcriptional regulators that mediate several carcinogenic pathways and the chemotherapy-induced tumor-supporting paracrine network
  • MED13, represses numerous thyroid receptor (TR) response genes in the heart
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRSSF
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Med13 expression is induced in the hearts of mice with hypothyroidism