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FLASH GENE

Symbol

NECAB2

contributors: mct/npt - updated : 03/01/2009

HGNC name	N-terminal EF-hand calcium binding protein 2
HGNC id	23746

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

antibiotic biosynthesis monooxygenase family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	regulatory calcium binding protein
	with ADORA2A, modulates the cell surface expression and function of the receptor (Canela 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with GRM5 (NECAB2 by its physical interaction with GRM5 modulates receptor function) (Canela 2009)
	binding partner for ADORA2A interacting with its C-terminal domain (interacts with NECAB2 in striatal neurones co-expressing the two proteins and the interaction is relevant for ADORA2A function)(Canela 2007)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS