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FLASH GENE
Symbol NECAB2 contributors: mct/npt - updated : 03/01/2009
HGNC name N-terminal EF-hand calcium binding protein 2
HGNC id 23746
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 1636 43 386 - Sugita (2002)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus  
Visualeye    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervouspyramidal cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • antibiotic biosynthesis monooxygenase family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulatory calcium binding protein
  • with ADORA2A, modulates the cell surface expression and function of the receptor (Canela 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GRM5 (NECAB2 by its physical interaction with GRM5 modulates receptor function) (Canela 2009)
  • binding partner for ADORA2A interacting with its C-terminal domain (interacts with NECAB2 in striatal neurones co-expressing the two proteins and the interaction is relevant for ADORA2A function)(Canela 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS