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FLASH GENE
Symbol NECAB2 contributors: mct/npt - updated : 03/01/2009
HGNC name N-terminal EF-hand calcium binding protein 2
HGNC id 23746
Location 16q24.1      Physical location : 84.002.236 - 84.036.377
Synonym name
  • neuronal calcium binding 2
  • EF hand calcium binding protein 2
  • synaptotagmin-interacting protein 2
  • Synonym symbol(s) EFCBP2, Stip-2
    DNA
    TYPE anonymous DNA segment
    STRUCTURE 34.14 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1636 43 386 - Sugita (2002)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus  
    Visualeye    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervouspyramidal cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • antibiotic biosynthesis monooxygenase family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • regulatory calcium binding protein
  • with ADORA2A, modulates the cell surface expression and function of the receptor (Canela 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GRM5 (NECAB2 by its physical interaction with GRM5 modulates receptor function) (Canela 2009)
  • binding partner for ADORA2A interacting with its C-terminal domain (interacts with NECAB2 in striatal neurones co-expressing the two proteins and the interaction is relevant for ADORA2A function)(Canela 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS