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FLASH GENE

Symbol

RAF1

contributors: mct - updated : 24-12-2018

HGNC name	v-raf-1 murine leukemia viral oncogene homolog 1
HGNC id	9829

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

LEOPS2 , NS5

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       in-frame oncogenic fusion between SRGAP3 and RAF1 in Pilocytic astrocytomas constitutional     --other   dysfunction (expression) of the FGFR1, SOS1 and RAF1 genes is involved in the development of unilateral or bilateral cryptorchidism tumoral fusion       with LRCH3, CTNNA1, GOLGA4, CTDSPL, MAP4, PRKAR2A in melanomas tumoral fusion       LRRFIP2-RAF1 fusion identified in an acral melanoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular valvulopathy   modulating the RAF1Ser(259)/14-3-3 protein-protein interaction with a stabilizing small molecule may yield a novel potential approach for treatment of diseases resulting from an overactive Ras-RAF-MAPK pathway, as Noonan or Leopard syndrome cancer     excellent molecular target for anticancer therapy

ANIMAL & CELL MODELS