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FLASH GENE
Symbol CABLES1 contributors: - updated : 21-02-2006
HGNC name Cdk5 and Abl enzyme substrate 1
HGNC id 25097
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivestomach    
Lymphoid/Immunethymus    
Respiratorylung    
 respiratory tractlarynx  highly
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal domain composed of 124 amino acids resembling the highly conserved cyclin box
    • HOMOLOGY
    interspecies ortholog to murine Cables1
    Homologene
    FAMILY cyclin-like protein
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • Cdk5 and Abl enzyme substrate 1
  • hormonally regulated and involved in regulating endometrial cell proliferation
    • CELLULAR PROCESS cell cycle, division
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interactor 1 with Cdk3
    cell & other
    REGULATION
    induced by by progesterone and down-regulated by estrogen in benign endometrium
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in endometrial hyperplasia and endometrial cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS