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FLASH GENE
Symbol CABLES1 contributors: - updated : 21-02-2006
HGNC name Cdk5 and Abl enzyme substrate 1
HGNC id 25097
DNA
TYPE functioning gene
STRUCTURE 122.00 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivestomach    
Lymphoid/Immunethymus    
Respiratorylung    
 respiratory tractlarynx  highly
Skin/Tegumentskin    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a C-terminal domain composed of 124 amino acids resembling the highly conserved cyclin box
    • HOMOLOGY
    interspecies ortholog to murine Cables1
    Homologene
    FAMILY cyclin-like protein
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • Cdk5 and Abl enzyme substrate 1
  • hormonally regulated and involved in regulating endometrial cell proliferation
    • CELLULAR PROCESS cell cycle, division
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interactor 1 with Cdk3
    cell & other
    REGULATION
    induced by by progesterone and down-regulated by estrogen in benign endometrium
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in endometrial hyperplasia and endometrial cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS