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FLASH GENE
Symbol ARHGAP22 contributors: mct - updated : 29-10-2012
HGNC name Rho GTPase activating protein 22
HGNC id 30320
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal PH domain, required for the 14-3-3 interaction
  • a RhoGAP domain, unlikely to participate in this interaction
  • a C-terminal coiled-coil domain
    • HOMOLOGY
    interspecies homolog to murine Arhgap22
    Homologene
    FAMILY RhoGap family of proteins
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • Rho GTPase activator activity
  • with DOCK3, NEDD9, WASF2, are key molecules regulating RAC1 and RHO signaling that determine the mode of movement driving melanoma cell metastasis
  • AKT1-dependent regulator of cell motility in response to insulin
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule GTP binding
    protein
  • interaction of the IL1RAPL1 family of proteins with PTPRD and ARHGAP22 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling that regulates excitatory synapse and dendritic spine formation
  • insulin-responsive 14-3-3 binding protein
  • AKT1 substrate that binds 14-3-3 proteins in response to treatment with growth factors involved in cell migration
    • cell & other
    REGULATION
    activated by Rho-kinase signaling, that activates ARHGAP22, and suppresses mesenchymal movement by inactivating RAC1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS