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FLASH GENE

Symbol

ARHGAP22

contributors: mct - updated : 29-10-2012

HGNC name	Rho GTPase activating protein 22
HGNC id	30320

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001256025 10 - 2712 NP_001242954 - 704 - 2011 21969604 NM_021226 10 - 2798 NP_067049 - 698 - 2011 21969604 NM_001256026 8 - 2352 NP_001242955 - 608 - 2011 21969604 NM_001256024 10 - 2846 NP_001242953 - 714 - 2011 21969604

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal PH domain, required for the 14-3-3 interaction
	a RhoGAP domain, unlikely to participate in this interaction
	a C-terminal coiled-coil domain

HOMOLOGY

interspecies

homolog to murine Arhgap22

Homologene

FAMILY

RhoGap family of proteins

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	Rho GTPase activator activity
	with DOCK3, NEDD9, WASF2, are key molecules regulating RAC1 and RHO signaling that determine the mode of movement driving melanoma cell metastasis
	AKT1-dependent regulator of cell motility in response to insulin

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

GTP binding

protein	interaction of the IL1RAPL1 family of proteins with PTPRD and ARHGAP22 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling that regulates excitatory synapse and dendritic spine formation
	insulin-responsive 14-3-3 binding protein
	AKT1 substrate that binds 14-3-3 proteins in response to treatment with growth factors involved in cell migration

cell & other

REGULATION

activated by

Rho-kinase signaling, that activates ARHGAP22, and suppresses mesenchymal movement by inactivating RAC1

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS