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FLASH GENE
Symbol OTOP3 contributors: mct - updated : 25-08-2022
HGNC name otopetrin 3
HGNC id 19658
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text fetal eyes, lens, eye anterior segment, optic nerve, retina, Retina Foveal and Macular, RPE and Choroid
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • multitransmembrane domain
  • dimeric and each subunit forming 12 transmembrane helices divided into structurally similar amino (N) and carboxy (C) domains
    • mono polymer dimer
    HOMOLOGY
    intraspecies paralog to OTOP1, OTOP2
    Homologene
    FAMILY
  • otopetrin family
    • CATEGORY
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • members of the OTOP channel family are proton-gated (acid-sensitive) proton channels and that the gating apparatus is distributed across multiple extracellular regions within both the N and C domains of the channels
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS