Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

OTOP3

contributors: mct - updated : 25-08-2022

HGNC name	otopetrin 3
HGNC id	19658

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	14.19 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_178233 7 - 1791 NP_839947 - 596 - 2003 12651873 NM_001272005 7 - 2337 NP_001258934 - 578 - 2003 12651873

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	fetal eyes, lens, eye anterior segment, optic nerve, retina, Retina Foveal and Macular, RPE and Choroid

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	multitransmembrane domain
	dimeric and each subunit forming 12 transmembrane helices divided into structurally similar amino (N) and carboxy (C) domains

mono polymer

dimer

HOMOLOGY

intraspecies

paralog to OTOP1, OTOP2

Homologene

FAMILY

otopetrin family

CATEGORY

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

members of the OTOP channel family are proton-gated (acid-sensitive) proton channels and that the gating apparatus is distributed across multiple extracellular regions within both the N and C domains of the channels

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS