| basic FUNCTION
| may be integral to the membrane vesicles that are released into the gelatinous membrane, which may foster lattice crystal formation  |
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involved in vestibular function |
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implicated in depletion of endoplasmic reticulum Ca(2+) stores, specific inhibition of P2RY2, and regulation of the influx of extracellular Ca(2+) in response to ATP, ADP, and UDP |
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is necessary for the formation of otoconia and otoliths, calcium carbonate biominerals within the inner ear of mammals and teleost fish that are required for the detection of linear acceleration and gravity |
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multitransmembrane domain protein, which is essential for mineralization of otoconia, the calcium carbonate biominerals required for vestibular function, and the normal sensation of gravity |
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acts potentially as a sensor of the extracellular calcium concentration near supporting cells and responds to ATP in the endolymph to increase intracellular calcium levels during otoconia mineralization |
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essential for the development of otoconia, the extracellular calcium carbonate containing crystals important for vestibular mechanosensory transduction of linear motion and gravity |
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modulate purinergic control of intracellular calcium in vestibular supporting cells, which could be one of the mechanisms by which OTOP1 participates in the mineralization of otoconia |
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protein required for development of gravity-sensing otoconia in the vestibular system, as forming a proton-selective ion channel |
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OTOP1 functions as a sour taste receptor |
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members of the OTOP channel family are proton-gated (acid-sensitive) proton channels and that the gating apparatus is distributed across multiple extracellular regions within both the N and C domains of the channels |
