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FLASH GENE
Symbol ESX1 contributors: mct - updated : 28-06-2012
HGNC name extraembryonic, spermatogenesis, homeobox 1 homolog (mouse)
HGNC id 14865
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal 45-kDa fragment containing the paired-like homeodomain, localized to the nucleus, acting as a sequence-specific transcriptional repressor
  • C-terminal 20-kDa fragment localizes to the cytoplasm and inhibits the degradation of mitotic cyclins, thereby inducing M phase cell-cycle arrest
  • one OAR domain
  • glutamic acid-rich and proline-rich N- and C-terminal regions
  • 12 repeats of a unique nine amino acid motif, PPMAP(V/L)PPG, located C-terminal to the homeodomain
    • HOMOLOGY
    interspecies ortholog to murine ESX1
    Homologene
    FAMILY paired homeobox family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • homeoprotein involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages
  • plays a role in concerted regulation of the cell cycle and transcription in cells
  • may be playing a role in post-meiotic germ cell development
  • involved in placental development and spermatogenesis
  • playing a potential role within the growth control mechanism of the fetus, through its effect on placental function
  • required for the translocation of Mycobacterium tuberculosis or Mycobacterium marinum to the cytosol of host cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with the TAATGTTATTA sequence that is present within the first intron of the K-ras gene termed REK, and represses KRAS transcription
  • NRK and ESX1 may participate in the same signaling pathway that regulates placental development
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in human pre-term idiopathic fetal growth restriction
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potentially reliable spermatogenesis molecular marker
    • Therapy target potential clinical application of TAT-mediated transduction of N-ESX1 in the treatment of cancers with K-ras mutations
    ANIMAL & CELL MODELS