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FLASH GENE
Symbol CTSA contributors: SGE - updated : 12-01-2010
HGNC name cathepsin A
HGNC id 9251
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer heteromer , dimer , polymer
HOMOLOGY
interspecies homolog to murine Ctsa (87.8pc)
homolog to rattus Ppgb (85.3pc)
Homologene
FAMILY
  • serine carboxypeptidase S10 family
    • CATEGORY chaperone/stress , enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • galactosidase, associated with esterase, deamidase, serine carboxypeptidase, cathepsin A activity, activity on selected neuropeptides, catalytic function distinct from the protective function
  • serine carboxypeptidase activity triggering the degradation of the lysosome-associated membrane protein type 2a (Cuervo 2003)
  • carboxypeptidase that can deamidate tachykinins (Galjart 1991)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with beta-galactosidase and neuramidase, providing a protective role for stability and activity
  • heterodimer 32-20kDa chains held together by disulfide bonds
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other targeted to the lysosome by M6P receptor mediated pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) GSL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS