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FLASH GENE
Symbol EMILIN3 contributors: mct - updated : 28-11-2017
HGNC name elastin microfibril interfacer 3
HGNC id 16123
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus     Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text perichondrium cells of developing limbs
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a characteristic N-terminal cysteine-rich EMI domain , spanning &
    • 8764;80 amino acids and characterized by the presence of highly conserved cysteine residues located at regular positions
  • lacking the gC1q domain in its C-terminal region
    • HOMOLOGY
    Homologene
    FAMILY (EMILIN)/Multimerin family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a significant role in the process of osteogenesis and in skeletal development
  • might play important roles in carcinogenesis of esophageal cancer
  • may potentially participate in the modulation in the extracellular space of the availability and distribution of other secreted factors known to be regulated by heparan sulfate proteoglycans
  • EMILIN3 modulates the availability of HH ligands by interacting with the permissive factor SCUBE2 in the notochord sheath
  • EMILIN1, EMILIN2, and EMILIN3 are microfibril-associated glycoproteins known to modulate cell behaviour, growth factor activity, and ECM assembly
  • role of EMILINs in dentinogenesis, pulp biology, and inflammation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forms disulfide-bonded homotrimers and higher order oligomers
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds heparin with high affinity and that this binding is mediated by the EMI domain (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS