Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

POMC

contributors: mct - updated : 03-05-2013

HGNC name	proopiomelanocortin
HGNC id	9201

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

OARH

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional fusion       aberrant fusion protein interfering with signalling through the MC4R and increasing the risk of obesity constitutional germinal mutation       associated with early onset obesity, adrenal insufficiency, and red hair pigmentation

Susceptibility

to obesity (early onset) to opioid dependence to alcohol dependence

Variant & Polymorphism other	mutation R236G
	8246C>T significantly associated with leptin and/or body fat deposition
	DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS