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FLASH GENE

Symbol

KDM2B

contributors: mct - updated : 24-11-2011

HGNC name	lysine (K)-specific demethylase 2B
HGNC id	13610

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a F-box domain
	a jmjC domain, necessary for the specific demethylation of trimethylated lysine 4 on histone H3 in the nucleolus
	two leucine-rich repeats
	a CXXC-type zinc finger

HOMOLOGY

interspecies

homolog to murine Fbxl10

intraspecies

paralog to the histone demethylase KDM2A

Homologene

FAMILY

JHDM (JmjC-domain-containing histone demethylase) family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	putative role in chromatin remodeling
	playing a role in cancer development
	negatively regulates rRNA gene expression
	H3K36 demethylase that regulates cell proliferation and senescence through CDKN2B
	JmjC domain-containing histone demethylase protecting cells from replicative senescence
	regulates redox homeostasis and protects cells from oxidative stress
	novel functional role for KDM2B as an anti-apoptotic molecule
	transcriptional repressor of FOS and a target gene of nuclear factor kappa-light-chain-enhancer of activated B cells
	having negative effect on cell size and cell proliferation
	important in regulating cell proliferation and cellular senescence
	potentially functioning as an oncogene and playing a critical role in leukemia development and maintenance

CELLULAR PROCESS

nucleotide, chromatin organization, remodeling

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

oncogenic pathway that functionally links FGF2 with EZH2 via KDM2B and miR-101

a component

INTERACTION

DNA	preferentially binds the transcribed region of ribosomal DNA to repress the transcription of ribosomal RNA genes

RNA

small molecule	nucleotide,
	ATP binding
	Zn2+ binding

protein

synergizes with EZH2 to silence the EZH2 inhibitor miR-101

cell & other

REGULATION

induced by

FGF2 via CREB phosphorylation and activation, downstream of DYRK1A, and mediates the FGF2 and EZH2 effects on cell proliferation, migration, and angiogenesis

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in various human leukemias

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     silencing KDM2B can help overcome resistant cancer cells for pro-apoptotic therapies

ANIMAL & CELL MODELS

about half of Fbxl10-deficient mice exhibit failure of neural tube closure, resulting in exencephaly and die shortly after birth