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FLASH GENE
Symbol TNPO3 contributors: mct - updated : 03-03-2020
HGNC name transportin 3
HGNC id 17103
Location 7q32.1      Physical location : 128.594.233 - 128.695.227
Synonym name
  • transportin-SR
  • importin 12
  • transportin-SR2
    • Synonym symbol(s) IPO12, MTR10A, TRN-SR, TRN-SR2, TRNSR, LGMD1F, LGMDD2, MTR10A
    DNA
    TYPE functioning gene
    STRUCTURE 100.99 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 3669 104.2 923 - 2019 30916345
    23 - 4230 - 859 - 2019 30916345
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • arginine-serine (RS) repeat domains (PMIS: 24449914)
    • HOMOLOGY
    Homologene
    FAMILY importin-beta family of nuclear import proteins
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nuclear envelope
    basic FUNCTION
  • playing a role in transport of phosphorylated serine-rich proteins
  • important role in human immunodeficiency virus type 1 (HIV-1) infection and preintegration complex (PIC) nuclear import
  • is required for lentivirus nuclear import
  • cellular cofactor of HIV replication that has been implicated in the nuclear import of HIV
  • cellular karyopherin implicated in nuclear import of HIV-1
  • is implicated in nuclear import of splicing factors and HIV-1 replication
  • the arginine/serine (RS)-like domain (RSLD) that mediates TNPO3 binding is critical, for CPSF6 nuclear import
  • involved in the nuclear transport of serine/arginine-rich proteins such as splicing factors and also in HIV-1 infection through interaction with the viral integrase and capsid
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibition of HIV-1 by TNPO3-depleted cells requires CPSF6
  • interaction of TNPO3 with Ras-related nuclear protein (Ran) GTPase
  • interaction of TNPO1 and TNPO3 with the nonclassical NLSs may regulate the formation of membraneless organelles and subcellular localization of numerous protein
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to primary biliary cirrhosis
    Variant & Polymorphism SNP rs10488631 at the locus IRF5-TNPO3, strongly assocated to primary biliary cirrhosis
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    inhibition of HIV-1 by TNPO3-depleted cells requires CPSF6 (PMID: 23622145)
    ANIMAL & CELL MODELS