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FLASH GENE
Symbol TNPO3 contributors: mct - updated : 17-11-2010
HGNC name transportin 3
HGNC id 17103
Location 7q32.1      Physical location : 128.594.233 - 128.695.227
Synonym name
  • transportin-SR
  • importin 12
  • Synonym symbol(s) IPO12, MTR10A, TRN-SR, TRN-SR2, TRNSR
    DNA
    TYPE functioning gene
    STRUCTURE 100.25 kb     23 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    NSG-X 7q31 brain and nasopharyngeal carcinoma susceptibility protein LRRC4 7q31 leucine rich repeat containing 4 LEP 7q31.3 leptin (obesity homolog, mouse) MGC27345 7q32.2 hypothetical protein MGC27345 FLJ10377 7q32.2 hypothetical protein FLJ10377 LOC389551 7 hypothetical gene supported by BC063892 IMPDH1 7q31.3-q32 IMP (inosine monophosphate) dehydrogenase 1 HIG2 7q32.2 hypoxia-inducible protein 2 METTL2 17q24.1 methyltransferase like 2 LOC389552 7 similar to Serine/threonine-protein kinase tousled-like 2 (Tousled-like kinase 2) (PKU-alpha) LOC389553 7 hypothetical gene supported by AL137733 LOC389554 7 hypothetical gene supported by BC062355 LOC392095 7 similar to capicua homolog LOC346653 7q32.2 hypothetical protein LOC346653 NYD-SP18 7q32.2-q32.3 testes development-related NYD-SP18 CALU 7q32 calumenin OPN1SW 7q31.3-q32 opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) DKFZP434G156 7q33 hypothetical protein DKFZp434G156 FLNC 7q32 filamin C, gamma (actin binding protein 280) ATP6V1F 7q32 ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F LOC389555 7 similar to Filamin C (Gamma-filamin) (Filamin 2) (Protein FLNc) (Actin-binding like protein) (ABP-L) (ABP-280-like protein) IRF5 7q32 interferon regulatory factor 5 TNPO3 7q32.3 transportin 3 LOC392096 7 similar to Triosephosphate isomerase (TIM) HCP20 7q32.3 cytochrome c, somatic pseudogene LOC286017 7q32.3 similar to mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MAP kinase kinase 2; MAPK/ERK kinase 2; dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2 MGC50844 7q32.3 hypothetical protein MGC50844 LOC154981 7q32.3 hypothetical LOC154981 SMO 7q31 smoothened homolog (Drosophila) KIAA0828 7q32.3 KIAA0828 protein KIAA1170 7q32.3 KIAA1170 protein NRF1 7q32 nuclear respiratory factor 1 UBE2H 7q32 ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 3669 104.2 923 - 1999 10366588
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • RS domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • playing a role in transport of phosphorylated serine-rich proteins
  • important role in human immunodeficiency virus type 1 (HIV-1) infection and preintegration complex (PIC) nuclear import
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to primary biliary cirrhosis
    Variant & Polymorphism SNP rs10488631 at the locus IRF5-TNPO3, strongly assocated to primary biliary cirrhosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS