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FLASH GENE

Symbol

CPOX

contributors: np - updated : 22-03-2007

HGNC name	coproporphyrinogen oxidase
HGNC id	2321

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	14.15 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000097 7 - 2714 NP_000088 - 454 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           pancreas exocrine         Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Nervous epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, growth/childhood

Text	liver, placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to murine Cpox
	ortholog to rattus cpox_predicted

Homologene

FAMILY

aerobic coproporphyrinogen III oxidase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,interspace

basic FUNCTION	antepenultimate step in heme biosynthesis
	catalysing the oxidative decarboxylation of coproporphyrinogen III to proto-porhyrinogen IX in the heme and chlorophyll biosynthetic pathways

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	iron

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CPOX

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS