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FLASH GENE
Symbol CPOX contributors: np - updated : 22-03-2007
HGNC name coproporphyrinogen oxidase
HGNC id 2321
Corresponding disease
CPOX coproporphyria, hereditary acute hepatic porphyria
Location 3q12.1      Physical location : 98.298.291 - 98.312.455
Synonym name
  • coproporphyrinogen oxidase (coproporphyria, harderoporphyria)
  • coproporphyrinogenase
  • coproporphyrinogen-III oxidase, mitochondrial
  • Synonym symbol(s) CPO, CPX, HCP, COX
    EC.number 1.3.3.3
    DNA
    TYPE functioning gene
    STRUCTURE 14.15 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2714 - 454 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     pancreas exocrine    
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousepithelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, growth/childhood
    Text liver, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Cpox
    ortholog to rattus cpox_predicted
    Homologene
    FAMILY
  • aerobic coproporphyrinogen III oxidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    basic FUNCTION
  • antepenultimate step in heme biosynthesis
  • catalysing the oxidative decarboxylation of coproporphyrinogen III to proto-porhyrinogen IX in the heme and chlorophyll biosynthetic pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • iron
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CPOX
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS