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FLASH GENE

Symbol

GART

contributors: mct - updated : 16-10-2024

HGNC name	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
HGNC id	4163

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         only in individuals with Down syndrome tumoral     --over   is associated with poor outcomes in colorectal cancer (CRC) patients and promotes the proliferation and migration of CRC cells tumoral     --over   in hepatocellular carcinoma (HCC)

Susceptibility

to Autism spectrum disorders (ASD)

Variant & Polymorphism other	blocking GART results in nearly the same effect in the metabolic network as folate depletion, and methylation defect to be a potential cause of ASD, due to the depletion of purine, and consequently S-adenosyl methionine (SAM), biosynthesis

Candidate gene	for a chemotherapeutic target for several decades
Marker	GART expression may be one of the causative factors for a poor prognosis in HCC
Therapy target

ANIMAL & CELL MODELS