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FLASH GENE
Symbol GART contributors: mct - updated : 16-10-2024
HGNC name phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
HGNC id 4163
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ATP-grasp domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Gart (86.5 pc)
    homolog to murine Gart (85.5 pc)
    Homologene
    FAMILY
  • GARS family
  • AIR synthase family
  • GART family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the third step of the de novo purine biosynthesis (see TFPS) leading to formylglycinamide ribonucleotide (FGAR)
  • phosphoribosyl glycineamide synthetase
  • pivotal enzyme in de novo purine synthesis, that mediates cellular apoptosis in many diseases
  • GART plays a critical role in the protection of cellular apoptosis and migration of intestinal epithelial cells to maintain the integrity of the epithelial barrier
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
  • component of the trifunctional enzyme
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • GART enhances the stability of RUVBL1 through methylating its K7 site, which consequently aberrantly activates the Wnt/CTNNB1 signaling pathway to induce tumor stemness
    • cell & other
    REGULATION
    induced by VGLL3 inducing GART expression and thereby confers de novo nucleotide-dependent cell proliferation in cancer cell
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    only in individuals with Down syndrome
    tumoral     --over  
    is associated with poor outcomes in colorectal cancer (CRC) patients and promotes the proliferation and migration of CRC cells
    tumoral     --over  
    in hepatocellular carcinoma (HCC)
    Susceptibility
  • to Autism spectrum disorders (ASD)
    • Variant & Polymorphism other
  • blocking GART results in nearly the same effect in the metabolic network as folate depletion, and methylation defect to be a potential cause of ASD, due to the depletion of purine, and consequently S-adenosyl methionine (SAM), biosynthesis
    • Candidate gene for a chemotherapeutic target for several decades
    Marker
  • GART expression may be one of the causative factors for a poor prognosis in HCC
    • Therapy target
    ANIMAL & CELL MODELS