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FLASH GENE
Symbol PFKL contributors: mct - updated : 22-09-2015
HGNC name phosphofructokinase, liver
HGNC id 8876
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer tetramer
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • energy patway
  • glycolytic efficiency, which is important for the survival of cancer cells, depends primarily on the preferential expression of PFKL over the PFKM and PFKP isoforms
  • is modified with OGT in cancer cells, and glycosylation is increased specifically under conditions associated with tumorigenesis and tumor growth
  • PFKL glycosylation contributes to cell proliferation and tumor growth
  • catalyses the committed step of the glycolytic pathway by converting fructose-6-phosphate to fructose-1,6-bisphosphate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    fructose metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NXN, a thioredoxin-related oxidoreductase, is a novel interacting partner of PFKL
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PFKL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    blocking PFKL glycosylation to enhance its activity and reset cellular metabolism toward normal cell growth could therefore provide a new strategy to combat cancer
    ANIMAL & CELL MODELS