Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PFKL contributors: mct - updated : 22-09-2015
HGNC name phosphofructokinase, liver
HGNC id 8876
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer tetramer
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • energy patway
  • glycolytic efficiency, which is important for the survival of cancer cells, depends primarily on the preferential expression of PFKL over the PFKM and PFKP isoforms
  • is modified with OGT in cancer cells, and glycosylation is increased specifically under conditions associated with tumorigenesis and tumor growth
  • PFKL glycosylation contributes to cell proliferation and tumor growth
  • catalyses the committed step of the glycolytic pathway by converting fructose-6-phosphate to fructose-1,6-bisphosphate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    fructose metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NXN, a thioredoxin-related oxidoreductase, is a novel interacting partner of PFKL
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PFKL
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    blocking PFKL glycosylation to enhance its activity and reset cellular metabolism toward normal cell growth could therefore provide a new strategy to combat cancer
    ANIMAL & CELL MODELS