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FLASH GENE
Symbol PDHA2 contributors: mct - updated : 29-06-2022
HGNC name pyruvate dehydrogenase (lipoamide) alpha 2
HGNC id 8807
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to PDHA1
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
intracellular,nucleus,nucleolus
basic FUNCTION
  • pyruvate dehydrogenase
  • potential substitute for PDHA1 if suitably expressed
  • methylation of the PDHA2 coding region can inhibit gene transcription (PMD: 22675509)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF70
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be used as a diagnostic marker in all cancer except bladder urothelial carcinoma and prostate adenocarcinoma
    • Therapy target
    ANIMAL & CELL MODELS