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FLASH GENE

Symbol

PDHA2

contributors: mct - updated : 29-06-2022

HGNC name	pyruvate dehydrogenase (lipoamide) alpha 2
HGNC id	8807

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	intronless

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005390 1 - 1387 NP_005381 - 388 - 1990 2249846

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatozoa Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

paralog to PDHA1

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,nucleus,nucleolus

basic FUNCTION	pyruvate dehydrogenase
	potential substitute for PDHA1 if suitably expressed
	methylation of the PDHA2 coding region can inhibit gene transcription (PMD: 22675509)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPGF70

related resource

MITOP database

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	could be used as a diagnostic marker in all cancer except bladder urothelial carcinoma and prostate adenocarcinoma
Therapy target

ANIMAL & CELL MODELS