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FLASH GENE
Symbol PDHA2 contributors: mct - updated : 08-01-2010
HGNC name pyruvate dehydrogenase (lipoamide) alpha 2
HGNC id 8807
Location 4q22.3      Physical location : 96.761.238 - 96.762.624
Synonym name
  • PDHE1-A type II
  • pyruvate dehydrogenase E1 component subunit alpha,
  • testis-specific form, mitochondrial
    Synonym symbol(s) PDHAL, MGC149517, MGC149518
    EC.number 1.2.4.1
    DNA
    TYPE functioning gene
    STRUCTURE 1.39 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure contains two CpG islands, one encompassing the core promoter region and extending into the open reading frame, the other exclusively located in the coding region
    MAPPING cloned Y linked N status provisional
    Physical map
    ATOH1 4q22 atonal homolog 1 (Drosophila) SMARCAD1 4q22-q23 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 PGDS 4q22.1-q23 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 LIM 4q22 LIM protein (similar to rat protein kinase C-binding enigma) LOC389213 4 similar to hypothetical protein FLJ33610 BMPR1B 4q23-q24 bone morphogenetic protein receptor, type IB UNC5C 4q21-q23 unc-5 homolog C (C. elegans) PDHA2 4q22-q23 pyruvate dehydrogenase (lipoamide) alpha 2 COX7A3 14 cytochrome c oxidase subunit VIIa polypeptide 3 (liver) MGC46496 4q22.3-q23 hypothetical protein MGC46496 RAP1GDS1 4q21 RAP1, GTP-GDP dissociation stimulator 1 TM4SF9 4q22.3 transmembrane 4 superfamily member 9 LOC132556 4q23 similar to Transcription factor BTF3 homolog 3 EIF4E 4q21-q25 eukaryotic translation initiation factor 4E METAP1 4q22.3 methionyl aminopeptidase 1 ADH5 4q21-q23 alcohol dehydrogenase 5 (class III), chi polypeptide ADH4 4q21-q24 alcohol dehydrogenase 4 (class II), pi polypeptide LOC359806 4q24 PCNA pseudogene p1PCNA ADH6 4q21-q25 alcohol dehydrogenase 6 (class V)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1387 - 388 - 1990 2249846
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatozoa Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • pyruvate dehydrogenase
  • potential substitute for PDHA1 if suitably expressed
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS