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FLASH GENE
Symbol ANXA4 contributors: - updated : 29-11-2006
HGNC name annexin A4
HGNC id 542
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a relatively short N terminus
  • a C terminal "core" region made of four repeats homolog to the endonexin fold
    • HOMOLOGY
    interspecies homolog to murine Anxa4
    homolog to C.elegans ZC155.1
    Homologene
    FAMILY annexin family of calcium-dependent phospholipid binding proteins
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • lipocortin IV, placental anticoagulant protein II,
    • inhibiting phospholipase A2, promoting membrane fusion
  • may be playing a role in synaptic exocytosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component complexing with rabphilin, and synaptotagmin 1
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide, other,
  • seems to bind one calcium ion with high affinity
  • phospholipid
  • ATP (maybe)
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS