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FLASH GENE

Symbol

ANXA4

contributors: - updated : 29-11-2006

HGNC name	annexin A4
HGNC id	542

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	44.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ANXA4 a - - 1982 - 321 widely Dedman, Piljic ANXA4b - - - - 321 only in the digestive tract Dedman ANXA4c - - - - 321 very restricted Dedman

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   stomach       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial

cells

System Cell Pubmed Species Stage Rna symbol   epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a relatively short N terminus
	a C terminal "core" region made of four repeats homolog to the endonexin fold

HOMOLOGY

interspecies	homolog to murine Anxa4
	homolog to C.elegans ZC155.1

Homologene

FAMILY

annexin family of calcium-dependent phospholipid binding proteins

CATEGORY

regulatory , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	lipocortin IV, placental anticoagulant protein II,
	inhibiting phospholipase A2, promoting membrane fusion
	may be playing a role in synaptic exocytosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

coagulation/hemostasis , exocytosis transport

PATHWAY

metabolism

signaling

a component

complexing with rabphilin, and synaptotagmin 1

INTERACTION

DNA

RNA

small molecule	metal binding, nucleotide, other,
	seems to bind one calcium ion with high affinity
	phospholipid
	ATP (maybe)

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS