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FLASH GENE
Symbol OXT contributors: mct/npt - updated : 18-01-2014
HGNC name oxytocin, prepropeptide
HGNC id 8528
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Oxt
homolog to C..elegans F17C11.2
Homologene
FAMILY
  • vasopressin/oxytocin family
    • CATEGORY signaling hormone , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • contracting smooth muscle during parturition and lactation
  • involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour as well as in the regulation of water excretion and cardiovascular functions
  • modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels
  • anabolic regulator of bone mass, with potential implications for osteoporosis therapy
  • can facilitate amygdala-dependent, socially reinforced learning and emotional empathy in men
  • potentially acting as a carbohydrate-specific inhibitor of feeding
  • primitive neurohypophyseal hormone that plays a primary and indispensible role in mammalian lactation
  • OXT produced from osteoblasts in response to estrogen acts upon its receptor to exert a potent anabolic action
  • can act as a neurotransmitter that reduces anxiety, promotes social behaviors and regulates food intake
  • OXT could be essential for the normal development of the serotoninergic system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text carrier protein neurophysin I
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    posterior pituitary hormone oxytocin
    a component
  • neurophysin 1 binding specifically to oxytocin which are two proteins encoded by the same gene
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • neurophysin 1 binding specifically to oxytocin
  • interacting with SYT4 (SYT4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased vesicle binding of SYT4 and thus enhanced negative regulation of oxytocin release)
  • relationship between FTO and OXT could thus be an important mechanism through which FTO exerts its effect on energy balance
  • GNAI2 plays an essential role in OXT and EGF signaling to induce prostate cancer cell migration
    • cell & other
    REGULATION
    repressed by SYT4 (negative regulation of SYT4 on oxytocin release represents a hypothalamic basis of neuropeptide exocytosis in controlling obesity and related diseases)
    Other activated while it is being transported along the axon to the posterior pituitary
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS