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FLASH GENE

Symbol

OXT

contributors: mct/npt - updated : 18-01-2014

HGNC name	oxytocin, prepropeptide
HGNC id	8528

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20p13      Physical location : 3.052.265 - 3.053.162
Synonym name	neurophysin I
	oxytocin-neurophysin I
	oxytocin, prepro- (neurophysin I)
Synonym symbol(s)	OT, OT-NPI, MGC126890, MGC126892

DNA

TYPE	functioning gene
STRUCTURE	0.89 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	pter - AVP /OXT , PDYN - D20S5 , D20S6 - cen

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000915 3 - 512 12.7 125 - 2011 21315262

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Homo sapiens Nervous brain diencephalon hypothalamus     Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Skeleton osteoblast Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

interspecies	homolog to murine Oxt
	homolog to C..elegans F17C11.2

Homologene

FAMILY

vasopressin/oxytocin family

CATEGORY

signaling hormone , transport carrier

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule

basic FUNCTION	contracting smooth muscle during parturition and lactation
	involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour as well as in the regulation of water excretion and cardiovascular functions
	modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels
	anabolic regulator of bone mass, with potential implications for osteoporosis therapy
	can facilitate amygdala-dependent, socially reinforced learning and emotional empathy in men
	potentially acting as a carbohydrate-specific inhibitor of feeding
	primitive neurohypophyseal hormone that plays a primary and indispensible role in mammalian lactation
	OXT produced from osteoblasts in response to estrogen acts upon its receptor to exert a potent anabolic action
	can act as a neurotransmitter that reduces anxiety, promotes social behaviors and regulates food intake
	OXT could be essential for the normal development of the serotoninergic system

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	carrier protein neurophysin I

PATHWAY

metabolism

signaling

hormonal , signal transduction

posterior pituitary hormone oxytocin

a component

neurophysin 1 binding specifically to oxytocin which are two proteins encoded by the same gene

INTERACTION

DNA

RNA

small molecule

protein	neurophysin 1 binding specifically to oxytocin
	interacting with SYT4 (SYT4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased vesicle binding of SYT4 and thus enhanced negative regulation of oxytocin release)
	relationship between FTO and OXT could thus be an important mechanism through which FTO exerts its effect on energy balance
	GNAI2 plays an essential role in OXT and EGF signaling to induce prostate cancer cell migration

cell & other

REGULATION

repressed by

SYT4 (negative regulation of SYT4 on oxytocin release represents a hypothalamic basis of neuropeptide exocytosis in controlling obesity and related diseases)

Other

activated while it is being transported along the axon to the posterior pituitary

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS