| basic FUNCTION
| involved in splicing mechanism |
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eliminating the production of nonsense-containing RNAs, essential for embryonic viability |
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involved in the DNA damage response (Suraweera 2007) |
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play a role in the response to oxidative stress, and plays a role in coordinating transcriptional events, in addition to its role in DNA repair (Suraweera 2009) |
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possible involvement of SETX in telomere stability  |
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role of senataxin in modulating the expression levels and signalling activity of fibroblast growth factor 8 |
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acts to resolve these R-loop structures and by so doing allows access of the 5 prime-3 prime exonuclease XRN2 at 3 prime cleavage poly(A) sites |
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colocalizes with TP53BP1, a key DNA damage response protein, and with other factors involved in DNA repair |
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is targeted to R loops, where it plays an important role at the interface of transcription and the DNA damage response |
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plays an important role in maintaining genome integrity by coordination of transcription, DNA replication, and the DNA damage response |
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is essential for spermatogenesis and it functions at two stages in meiosis during crossing-over in homologous recombination and in meiotic sex chromosome inactivation |
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key roles for senataxin in coordinating meiotic crossing-over with transcription and in gene silencing to protect the integrity of the genome |
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involved in the response to oxidative stress and likely resolve R loops formed at transcription termination sites or at sites of collisions between the transcription and replication machineries |
