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FLASH GENE

Symbol

MYL3

contributors: - updated : 13-07-2006

HGNC name	myosin, light polypeptide 3, alkali; ventricular, skeletal, slow
HGNC id	7584

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic thymus       highly Cardiovascular heart       highly Digestive liver         Respiratory lung       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Muscular striatum cardiac     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

muscle

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

three EF-hand domains

secondary structure

two heavy chains and four light chains

mono polymer

hexamer

HOMOLOGY

interspecies

homolog to murine Mylc

Homologene

FAMILY

CATEGORY

motor/contractile , structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton

basic FUNCTION

modulating the interaction between myosin and actin

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cardiovascular

PATHWAY

metabolism

signaling

a component

myosin is an hexamer of 2 heavy chains and 4 light chains

INTERACTION

DNA

RNA

small molecule

protein

CASP3 (cleavage of MYL3 contributing to depression of myocyte function)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CMH8

related resource

FHC Mutation Database

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS