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FLASH GENE
Symbol MYL1 contributors: mct - updated : 07-09-2016
HGNC name myosin, light polypeptide 1, alkali; skeletal, fast
HGNC id 7582
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transcriptional domains with left and right compoment
  • two heavy chains and four light chains
  • three EF-hand domains
    • mono polymer hexamer
    HOMOLOGY
    interspecies homolog to murine Mylf
    homolog to Drosophila Mlc-c
    homolog to C.elegans T12D8.6
    Homologene
    FAMILY
    CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulatory light chain of myosin
  • play a vital role in embryonic, fetal, and adult skeletal muscle development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component hexameric ATPase cellular motor protein composed of two heavy chains, two nonphosphorylable alkali light chains and two phosphorylable regulatory light chains
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
  • PARD3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MYL1 phosphorylation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism other
  • polymorphism of intron MYL1 was associated with endurance performance, specifically in endurance trainability
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS