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FLASH GENE
Symbol MX2 contributors: mct - updated : 14-05-2014
HGNC name myxovirus (influenza virus) resistance 2 (mouse)
HGNC id 7533
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nuclear localization signal (NLS) is present at the N-terminal end of the nuclear form but is lacking in the cytoplasmic form, basic nuclear localization signal (NLS) contained within its N-terminal 25 amino acids, and strictly required for antiviral activity
  • a GED domain
    • HOMOLOGY
    interspecies homolog to murine Mx2 and Mx1
    homolog to C.elegans T12E12.4
    intraspecies homolog to MX2
    Homologene
    FAMILY
  • dynamin family
  • IFN-inducible guanosine triphosphatase (GTPase) superfamily
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    text
  • having a nuclear and a cytoplasmic form
  • the nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope
  • only MX2 is localized to the nucleus (not MX1) (PmID: 24121441)
    • basic FUNCTION
  • is a narcolepsy-specific dysregulated gene, and there exists a relationship between the HLA-DQB1*0602 allele and MX2 gene expression
  • MX1 and MX2 are intracellular proteins that are induced exclusively by type I IFNs
  • potent inhibitor of HIV-1 infection and as a key effector of IFNA2-mediated resistance to HIV-1 infection, but is ineffective against influenza virus
  • MX2 inhibits the nuclear accumulation and integration of HIV-1 reverse transcripts
  • inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes
  • is an effector in the anti-HIV-1 activity of type I IFN
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
    cell & other
    REGULATION
    activated by by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1
    induced by interferon-alpha
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    in multiple sclerosis, MX1 and MX2 proteins are detectable in plaques suggesting endogenous synthesis of type I IFNs as part of the acute inflammatory process
    constitutional     --low  
    significantly less expressed in comparison with normal subjects in the white blood cells of narcoleptic patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinfectious 
    purposeful mobilization may represent a new therapeutic approach for the treatment of HIV/AIDS
    ANIMAL & CELL MODELS