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FLASH GENE

Symbol

MX2

contributors: mct - updated : 14-05-2014

HGNC name	myxovirus (influenza virus) resistance 2 (mouse)
HGNC id	7533

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly   thymus       highly Cardiovascular heart         Endocrine pancreas         Lymphoid/Immune lymph node       highly Reproductive male system prostate       Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a nuclear localization signal (NLS) is present at the N-terminal end of the nuclear form but is lacking in the cytoplasmic form, basic nuclear localization signal (NLS) contained within its N-terminal 25 amino acids, and strictly required for antiviral activity
	a GED domain

HOMOLOGY

interspecies	homolog to murine Mx2 and Mx1
	homolog to C.elegans T12E12.4

intraspecies

homolog to MX2

Homologene

FAMILY	dynamin family
	IFN-inducible guanosine triphosphatase (GTPase) superfamily

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,chromatin/chromosome,heterochromosome
text	having a nuclear and a cytoplasmic form
	the nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope
	only MX2 is localized to the nucleus (not MX1) (PmID: 24121441)

basic FUNCTION	is a narcolepsy-specific dysregulated gene, and there exists a relationship between the HLA-DQB1*0602 allele and MX2 gene expression
	MX1 and MX2 are intracellular proteins that are induced exclusively by type I IFNs
	potent inhibitor of HIV-1 infection and as a key effector of IFNA2-mediated resistance to HIV-1 infection, but is ineffective against influenza virus
	MX2 inhibits the nuclear accumulation and integration of HIV-1 reverse transcripts
	inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes
	is an effector in the anti-HIV-1 activity of type I IFN

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein

cell & other

REGULATION

activated by

by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1

induced by

interferon-alpha

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   in multiple sclerosis, MX1 and MX2 proteins are detectable in plaques suggesting endogenous synthesis of type I IFNs as part of the acute inflammatory process constitutional     --low   significantly less expressed in comparison with normal subjects in the white blood cells of narcoleptic patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology infectious   purposeful mobilization may represent a new therapeutic approach for the treatment of HIV/AIDS

ANIMAL & CELL MODELS