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FLASH GENE

Symbol

MX2

contributors: mct - updated : 14-05-2014

HGNC name	myxovirus (influenza virus) resistance 2 (mouse)
HGNC id	7533

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

text	an alternate translation start codon

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed nuclear form - - - 78 - localized in a granular pattern in the heterochromatin region beneath the nuclear envelope 1996 8798556 a nuclear localization signal (NLS) is present at the amino terminal end NM_002463 14 initiation site 2961 NP_002454 82 715 cytoplasmic form 1996 8798556 lacking the nuclear localization signal (NLS) due to use of an alternate translation start codon

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly   thymus       highly Cardiovascular heart         Endocrine pancreas         Lymphoid/Immune lymph node       highly Reproductive male system prostate       Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a nuclear localization signal (NLS) is present at the N-terminal end of the nuclear form but is lacking in the cytoplasmic form, basic nuclear localization signal (NLS) contained within its N-terminal 25 amino acids, and strictly required for antiviral activity
	a GED domain

HOMOLOGY

interspecies	homolog to murine Mx2 and Mx1
	homolog to C.elegans T12E12.4

intraspecies

homolog to MX2

Homologene

FAMILY	dynamin family
	IFN-inducible guanosine triphosphatase (GTPase) superfamily

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,chromatin/chromosome,heterochromosome
text	having a nuclear and a cytoplasmic form
	the nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope
	only MX2 is localized to the nucleus (not MX1) (PmID: 24121441)

basic FUNCTION	is a narcolepsy-specific dysregulated gene, and there exists a relationship between the HLA-DQB1*0602 allele and MX2 gene expression
	MX1 and MX2 are intracellular proteins that are induced exclusively by type I IFNs
	potent inhibitor of HIV-1 infection and as a key effector of IFNA2-mediated resistance to HIV-1 infection, but is ineffective against influenza virus
	MX2 inhibits the nuclear accumulation and integration of HIV-1 reverse transcripts
	inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes
	is an effector in the anti-HIV-1 activity of type I IFN

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein

cell & other

REGULATION

activated by

by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1

induced by

interferon-alpha

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   in multiple sclerosis, MX1 and MX2 proteins are detectable in plaques suggesting endogenous synthesis of type I IFNs as part of the acute inflammatory process constitutional     --low   significantly less expressed in comparison with normal subjects in the white blood cells of narcoleptic patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology infectious   purposeful mobilization may represent a new therapeutic approach for the treatment of HIV/AIDS

ANIMAL & CELL MODELS