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FLASH GENE
Symbol MX1 contributors: mct - updated : 14-10-2009
HGNC name myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
HGNC id 7532
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a tripartite GTP-binding domain consisting of GxxxxGKS, DxxG and TKxD
    • HOMOLOGY
    interspecies ortholog to murine Mx2
    ortholog to rattus mx2
    intraspecies homolog to MX2
    Homologene
    FAMILY
  • dynamin family
  • family of large GTPases
    • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • GTPase
  • induction of apoptosis
  • regulatory protein involved in Ca2+ signaling
  • showing activity against influenza virus and vesicular stomatitis virus (VSV) a rhabdovirus
  • recognizes the viral nucleocapsid protein and interferes with its role in viral genome replication
  • having certain characteristics of the stress proteins
  • inhibits tumor cell motility and invasion
  • MX1 and MX2 are intracellular proteins that are induced exclusively by type I IFNs
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • self-assemble into homo-oligomers in vitro
    • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • GTP
  • mg2+
    • protein
  • binding to elements of the cytoskeleton, such as actin and tubulins
  • interacts with the second ankyrin-like repeat domain of TRPC6 and interacted with TRPC1, -3, -4, -5, and -7 (regulated the activity of TRPC6 by a mechanism requiring GTP binding)
    • cell & other
    REGULATION
    induced by interferons (alpha and beta at least)
    by small molecules
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in end-stage dilated cardiomyopathy
    tumoral     --low  
    by hypermethylation in head and neck tumors
    constitutional     --other  
    in multiple sclerosis, MX1 and MX2 proteins are detectable in plaques suggesting endogenous synthesis of type I IFNs as part of the acute inflammatory process
    Susceptibility susceptibility factor for alopecia areata
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    its expression can be induced by small molecules, potentially offering a new approach to the prevention and treatment of metastasis
    ANIMAL & CELL MODELS