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FLASH GENE
Symbol MDH1 contributors: mct - updated : 13-11-2020
HGNC name malate dehydrogenase 1, NAD (soluble)
HGNC id 6970
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Mor2
homolog to C.elegans f46e10.10
intraspecies homolog to KETAR (keto acid reductase,alpha-1)
Homologene
FAMILY
  • IDH family, MDH subfamily
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria
  • catalyzing the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle
  • adipogenic differentiation may be regulated by the acetylation of MDH1 and that the acetylation of MDH1 is one of the cross-talk mechanisms between adipogenesis and the intracellular energy level
  • cytosolic MDH1 activity helps support glycolysis in actively proliferating cells and cancer
  • MPP7 and MDH1 are novel regulators of autophagy, which is thought to be responsible for pancreatic cancer cell survival
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text malate-aspartate shuttle
    PATHWAY
    metabolism
    signaling
    citric acid cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
    NAD +
    protein
  • MDH1 functions likely as a transcriptional regulator for a TP53-dependent metabolic checkpoint
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EIEE88
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in left ventricular cardiac muscle of dilated cardiomyopathy (DCM) patients
    constitutional     --over  
    in sporadic Creutzfeldt-Jakob disease (sCJD) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential of MDH1 in combination with tau as an additional biomarker in sCJD improving diagnostic accuracy of tau markedly
    • Therapy target
    ANIMAL & CELL MODELS